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Residual Solvents Instrumentation

Mass Spectral Analysis
Cannabis Leaf

Gas chromatography-mass spectrometry with headspace sampling (GC/MS/HS) is a powerful analytical technique used to detect residual solvents in cannabis products. In this method, a sample of the cannabis product is placed in a sealed vial and heated to release volatile compounds into the headspace. The headspace is then injected into a gas chromatograph, where the compounds are separated based on their chemical properties.


As the compounds elute from the chromatographic column, they enter a mass spectrometer, which identifies and quantifies them based on their mass-to-charge ratio.

This technique is crucial for product safety in the cannabis industry because residual solvents left in cannabis extracts can pose health risks to consumers if ingested or inhaled. Solvents such as butane, hexane, and ethanol, which are commonly used in extraction processes, can leave behind residues in the final product. If these residues exceed safe levels, they can lead to adverse health effects such as respiratory irritation, dizziness, and nausea.


By employing GC/MS/HS, cannabis producers can accurately identify and quantify residual solvents in their products, ensuring compliance with regulatory limits and safeguarding consumer health. This analytical method provides precise and reliable results, allowing manufacturers to take appropriate measures to remove or minimize solvent residues during production. Overall, GC/MS/HS plays a vital role in ensuring the safety and quality of cannabis products, thereby enhancing consumer confidence in the industry.

Cannabis Leaf
Cannabis Concentrate

Residual Solvents Analysis

Cannabis ChemLab provides precise residual solvent testing for cannabis products using advanced techniques like GC/MS/HS. Our experienced team ensures compliance with regulations and guarantees product safety. Trust us for accurate results and peace of mind.


Headspace sampling heats a sealed cannabis sample, causing volatile compounds like residual solvents to vaporize into the headspace above. This headspace is then analyzed, providing accurate detection of residual solvents without interfering with non-volatile components.

Agilent GC/MS/HS
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